Maximillion Pegasus created 3 Duel Monsters cards, who were known as the Wicked Gods to keep his Egyptian Gods in check, but stopped their production due to his fear of their immense power. After Pegasus passed away, Yako Tenma completed what Pegasus had left behind of the three Wicked Gods.
Yako possessed his brother, Gekko Tenma, to Duel Yugi Mutou to enact revenge on him. Yako used one of the copies of "The Wicked Dreadroot" against Yugi, but, ultimately, Yugi used "Spellbinding Illusion" to weaken "Dreadroot" as well as negate his effect of halving the ATK of all monsters on the field, and with "Lightning Blade", Yugi's monster was able to destroy it. However, Yako revealed that he the point of the Duel was to be able to Summon "The Wicked Dreadroot", allowing him to detach the soul of Anzu Mazaki for the R.A Project.
When Gekko allied with Yugi, he tore up his copy of "The Wicked Dreadroot", leaving Yako with the last copy of this card.
Due to the Summoning of "The Wicked Dreadroot" and "The Wicked Avatar" during this Duel, Yako was able to revive Pegasus, though it ultimately failed thanks to Kaiba.
The Wicked Dreadroot appears in the video games, Yu-Gi-Oh! Ultimate Masters: World Championship 2006 and Yu-Gi-Oh! World Championship 2007. In World Championship 2006, he appears as a Limited Duelist and he challenges the player to only included DARK monsters in the Deck. In World Championship 2007, he appears as a Level Four Theme Duelist and he challenges the player to successfully summon "Dark Dreadroute" and win the duel. By beating him, the player gets closer to unlocking Level Five Theme Duelists and a new Booster Pack.
In World Championship 2006, The Wicked Dreadroot plays a DARK Deck titled, "The Permadark". In World Championship 2007, he plays a Stall Deck titled, "Dark Rebirth".