Grand Mole first appeared when Jaden drew him during a Duel against Lorenzo. He used Grand Mole against "Big Core", he attacked Big Core and used his effect. By activating his effect, Jaden returned Grand Mole into his hand and "Big Core" into Lorenzo's hand. Through Grand Mole, Jaden was able to stop Lorenzo's "Boss Rush" combo and defeat him.
Neo-Spacian Grand Mole appears in Yu-Gi-Oh! World Championship 2007. He appears as a Level Four Limited Duelist and he challenges the player not to use monsters with an ATK/DEF of 1000 or more. By beating him, the player gets closer to unlocking Level Five Limited Duelists and a new Booster Pack.
In World Championship 2007, Neo-Spacian Grand Mole uses a Lockdown Deck tilted, "Under 1000".