Miho appeared once in the manga in a story where Hiroto Honda bought her a love jigsaw puzzle. In Toei's anime, she was made into a main character, alongside Yugi Mutou, Anzu Mazaki, Hiroto Honda and Jonouchi. Her role and personality in the anime are significantly different, and Honda has a massive crush on Miho throughout the series. The jigsaw puzzle story is changed in the anime to revolve around Mayumi buying the puzzle for Jonouchi.
Miho's usual outfit is the Domino High School's girls' uniform. She has lilac hair that is fixed in a ponytail and usually has a yellow ribbon on top. Miho is fair skinned.
Miho is cheerful and flirty, though she can also be a stubborn and resilient girl who nonetheless cares deeply for her friends' safety. She often refers to herself in the third-person. Miho shows signs of being a typical fangirl, squealing in delight at any given moment when an attractive male (mainly Ryo Bakura) walks past. Much like Honda, she is a romanticist at heart. However, Miho can also be naive and at times a little dim-witted and oblivious to the feelings of those around her, much to Honda's dismay. However, it is also hinted that Miho is aware of Honda’s crush on her, as she often says things in front of Honda on purpose so he will volunteer to do things for her.
If someone hurts her friends, she will get serious and come to their defense, as shown when she confronted Warashibe for giving Anzu, Honda and Jonouchi tainted water and making them sick.
Her first name means "beautiful" and "grain".
Miho entered the classroom while Jonouchi was tormenting Yugi. She said that the cafeteria line was long, and she had had nothing for lunch, prompting Honda to volunteer to buy her lunch.
After school one day, Jonouchi and Yugi agreed to go to Burger World on the way home. Honda disagreed, as it would be against school rules. Miho enthusiastically said that she'd like to go, causing Honda to change his mind. Anzu tried to discourage them from going, by saying she'd heard bad things about the place and reminded them of the escaped convict, Jiro the Jorogumo. Jonouchi noted how Anzu had been acting weird lately and not accompanying them on their way home from school over the last few days. He wondered if Anzu could be dating older men for pay. Miho, not wanting Anzu to live such a life, followed her home to try and "rescue her". However, she found that Anzu was actually working at Burger World, but kept it a secret as part-time jobs were against school rules. Miho too got a job at Burger World, wanting the extra money to buy things. She accompanied Anzu on her way home after school the next day. Honda suspected Miho was also dating for pay and followed, resulting in him getting a job too, wanting the extra money to buy stuff for Miho. The three were followed home by Yugi and Jonouchi the next day. Two escaped convicts entered Burger World that day and one of them wound up taking Anzu hostage. Miho, Honda and Anzu quit after this incident. Honda and Miho, however, got a new job at a noodle shop.
Honda was convinced by Miho to get up early to wait in line to buy a D-Shock watch for her. However, the watch got stolen by Shotaro Akaboshi while Honda wasn't paying attention. At the arcade, when Miho arrived to collect the watch, Honda discovered that it was missing and stripped down to his underwear while searching his clothes for it; as a result, Miho slapped him and ran off crying. Yami Yugi won the watch back in a Shadow Game and returned it to Honda, who passed it on to Miho. Two days later, Honda offered to wait in line to buy Miho some perfume. She was delighted to receive more gifts from Honda.
Miho got a Digital Pet and hoped to win the prize holiday in an upcoming tournament. However, she didn't want to spend time training the pet for the tournament herself, so she made sure to say this in front of Honda, who volunteered to take care of the pet. Honda took 3 days off school and returned with the pet, now named Super Strawberry, which he used to defeat Kujirada's pet Devil Master, who was busy eating Anzu and Jonouchi's pets. Haiyama, who had been manipulating Kujirada, kidnapped Miho and left a note for Honda to find. Honda attempted to rescue Miho, but was whipped into unconsciousness by Haiyama, who intended to have him replace Kujirada as his "pet". While he was unconscious, Yami Yugi defeated Haiyama in a Shadow Game. As Miho lay unconscious on Honda, she spoke about going on the holiday, but with her mother rather than Honda.
Mayumi had a crush on Jonouchi. Looking for ideas in what gift to get him, she asked Miho and Anzu what Jonouchi was interested in. Miho said porn videos, but after realizing that Mayumi was looking for a gift, they got Yugi to help and ended up getting a jigsaw love letter.
The college student Warashibe desperately tried to win Miho's affection by sending her Capsule Monster Chess pieces as presents. Warashibe pretended to be a hero in front of Miho by saving her from a thug, who was really Yugi in disguise. However, Miho recognized Yugi and Warashibe's appearance, which didn't meet her expectations. Warashibe tried to invite Miho to his secret base, but she refused and slapped him after getting too creeped out. Embarrassed by what happened, Warashibe poisoned Miho's friends with tainted water, prompting her to confront him. Yugi led her to Warashibe's base, where she was forced into a game of Capsule Monster Chess. Upon realizing that Warashibe had rigged the dispenser to give Miho incredibly weak monsters, Miho angrily got up to leave. Warashibe refused to let them leave, as he wanted to put Miho in a giant CapMon capsule. He quickly closed his gate, which broke, causing a part of it to hit Miho and Yugi, knocking them out. Yugi then transformed into Yami Yugi and defeated Warashibe, subjecting him to a Penalty Game and rescuing Miho.
When Yugi and Anzu went to Domino Park together, Miho, Jonouchi and Honda investigated to see if it was actually a date. Miho lashed out at Honda after he suggested that they go to the pool so he could see her in a swimsuit. Regardless, she still spent time with Honda in the pool. She managed to get out of the park during the evacuation when there was a bomb scare, but returned after the bomber was captured.
Miho congratulated Yugi after he received a love letter from Risa Kageyama and asked Anzu if she felt jealous. She continued to spy on Yugi's love life, by hiding in the bushes with the rest of his friends to watch Yugi meeting Risa.
Honda tried talking Miho into taking part in a beauty pageant. After Miho fell for Bakura, she agreed to do it. Fellow contestant Kaoruko Himekoji and her supporter, the Student Council Chairman, tried to sabotage Miho's chances of winning. Miho performed majorette dancing in the first round. The chairman had her swimsuit torn-up for the next round, but Miho improvised and wore a mermaid costume from the school drama supplies. Before the final round, Kaoruko knocked Miho unconscious and tore her dress. Yami Yugi then defeated Kaoruko in a Shadow Game, causing her to withdraw from the competition as well.
In Yu-Gi-Oh! The Movie, she hung out with her friends at school and had a good time with them. Miho, Honda, Yugi and Jonouchi head to a card shop to watch Yugi and Jonouchi play a game of Duel Monsters. Much to the gang's shock, they discovered that Anzu now worked there. Miho watched Yugi play the game as he explained it to her. Honda challenged her, but she wanted to watch some more. Shougo Aoyama was being picked on because he could not play the game very well. Anzu explained that the child had been there before, but was too timid to play.
Miho's final appearance was her having a good time with her friends and Shougo.
Miho dueled Yugi once, but none of her cards were shown.
Miho and Anzu are best friends. They support each other and rarely fight. Miho likes to tease her when Yugi goes out with another girl. Despite that, both girls are often together.
Miho Nosaka has a crush on Ryo Bakura. When she first met him, she intended on inviting him to her school. Miho strongly defends Bakura, even going to the point of saying unrealistic things about him. Bakura is Miho's official love interest.
- Yu-Gi-Oh! (Toei) episode 12: "A Lucky Foe Calls Out - The Invincible Legend"
- Yu-Gi-Oh! (Toei) episode 21: "Completed!! The Ultimate Game Land"
- Yu-Gi-Oh! (Toei) episode 1: "The Violent Battle - A Game of Darkness"
- Yu-Gi-Oh! (Toei) episode 2: "The Evil Gamer - The Trap of Hell"
- Yu-Gi-Oh! (Toei) episode 3: "Clash! The Strongest Monster"
- Yu-Gi-Oh! (Toei) episode 4: "Theft! Rare Watch Battle"
- Yu-Gi-Oh! (Toei) episode 7: "The Underhanded Digital Pet Rebellion"
- Yu-Gi-Oh! (Toei) episode 10: "The Pressing Beautiful Teacher - A Secret Mask"
- Yu-Gi-Oh! (Toei) episode 11: "The Rumored Capmon's New Appearance"
- Yu-Gi-Oh! (Toei) episode 14: "In a Bomb Game - The Worst Date"
- Yu-Gi-Oh! (Toei) episode 15: "Eerie Woman!! Unable to Transform"
- Yu-Gi-Oh! (Toei) episode 19: "The Grand Melee!! Popularity Contest"