MC can refer to:
- MC, a Yu-Gi-Oh! 5D's character.
- MC, an unnamed Yu-Gi-Oh! VRAINS character.
Other characters have also acted as MCs, but have not been referred to as such, including Mr. Heartland, Nico Smiley and Melissa Trail.
- Capsule Monster Chess, sometimes referred to as Monster Capsule, or MC.
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