In Yu-Gi-Oh! Duel Monsters 7: The Duelcity Legend and Yu-Gi-Oh! The Sacred Cards, Ishizu meets the player at the museum. She shows him the a stone tablet and explains that Duel Monsters stems from Ancient Egypt, where the Egyptians sealed powerful monsters in stone tablets to save the planet from destruction. She then Duels the player to see if he is strong enough to defeat her brother, Marik and stop him acquiring the Egyptian God cards. She then arranges for the player to Duel Seto Kaiba, to see which of them is more worthy of wielding an Egyptian God. When the player wins, she gives him "Obelisk the Tormentor". After the player defeats Marik, she congratulates him and takes back the Egyptian Gods.
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