- This is the main card of the 1999 Yu-Gi-Oh! movie produced by Toei Animation. In the movie, the card is owned by Shougo Aoyama. It's also stated in the movie that "Blue-Eyes" represents power while "Red-Eyes" represents potential.
- Another theme regarding the two Monsters and certain cards in their archetypes is violence/anger (Red-Eyes) and destruction/pride (Blue-Eyes). This is alluded to by their descriptions in Yu-Gi-Oh! The Sacred Cards.
- "Inferno Fire Blast", "Red-Eyes Burn", "Red-Eyes Black Flare Dragon", "Red-Eyes Flare Metal Dragon", "Archfiend Black Skull Dragon", and "Meteor Black Comet Dragon" all inflict Burn damage.
- "Blue-Eyes White Dragon", "Blue-Eyes Ultimate Dragon", "Blue-Eyes Alternative White Dragon" "Blue-Eyes Twin Burst Dragon", "Neo Blue-Eyes Ultimate Dragon", "Burst Stream of Destruction", and "Neutron Blast" revolve around destroying the opponents' cards.
- These archetypes' traits arguably describe the characters that represent their archetypes. "Red-Eyes" and its wrathful connotation could describe Joey Wheeler's past as a bully and temperament when ridiculed. "Blue-Eyes" and its references to destruction and power could represent Seto Kaiba and his vanity.
- Prior to its reprint in Legendary Duelists: Season 1, this card was known as "Red-Eyes B. Dragon" in the TCG, with the B. standing for "Black", as confirmed by its pronunciation in the English-dubbed anime and this card's translated Japanese name.
- This card has several counterparts:
- A metal counterpart: "Red-Eyes Black Metal Dragon"
- An egg counterpart: "The Black Stone of Legend"
- Two baby counterparts: "Black Dragon's Chick" and "Red-Eyes Baby Dragon".
- Two younger counterparts: "Red-Eyes Wyvern" and "Red-Eyes Retro Dragon".
- A Gemini counterpart: "Red-Eyes Black Flare Dragon".
- A "Malefic" counterpart: "Malefic Red-Eyes Black Dragon"
- A "Toon" counterpart: "Red-Eyes Toon Dragon"
- A LIGHT counterpart: "Blue-Eyes White Dragon"
- A Zombie counterpart: "Red-Eyes Zombie Dragon"
- An "evolved" counterpart: "Red-Eyes Darkness Dragon", which itself has its own metal and zombie counterparts, "Red-Eyes Darkness Metal Dragon" and "Red-Eyes Zombie Dragon Lord"
- Unlike "Dark Magician" and "Blue-Eyes White Dragon", this card does not have a Match Winner counterpart.
- This monster appears in the artworks of "Red-Eyes Burn", "Red-Eyes Spirit", "Inferno Fire Blast", "The Rival's Name", "Red-Eyes Insight", and "Cyberdark Invasion".
- This monster's silhouette appears in the artwork of "Red-Eyes Black Dragon Sword", reflecting the fact that in the anime, it was formed when Joey Wheeler fused this monster and "The Claw of Hermos" together.
- This card's first OCG/TCG artwork is taken from Yu-Gi-Oh! Duelist Duel 27: "The Secret Weapon", specifically from the panel showing this monster being Summoned.
- The Bandai version of this card has 2400 DEF, while this card has 2000 DEF.
- "Red-Eyes Black Dragon" has 3 claws in its first and second OCG/TCG artworks, while the third, fourth, and fifth artworks have 4 claws.
- During the Waking the Dragons story arc, this was the only "ace monster" of the three main characters (Yugi, Joey, and Kaiba) that was never affected by "The Seal of Orichalcos".
- Red-Eyes Black Dragon has a similar design to Ridley, a boss from Nintendo's Metroid series.