- This card's name comes from the Egyptian God, Isis.
- This card appears in the artwork for "Hieratic Seal of Convocation".
- This card appears to be similar to "Hieratic Dragon of Nebthet", though the wings are colored red.
- This is a reference to the mythology of Nephthys disguising herself as Isis to seduce Osiris, as well as the fact that they are both Level 5 and have similar stats.
- The two cards are also mirror images of each other, with Nephthe having a moon in the background while Eset has a sun. They both have similar coloration and posture as well, hinting that these two dragons might be twins.
- Like her sister, this card has a helmet image bearing a hieroglyphic symbol. In this card, it is the throne symbol of Isis.
- This card's sealed form appears in "Hieratic Seal of the Heavenly Spheres".
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