- This monster is based off the Dungeons & Dragons representation of a Mesopotamian goddess, Tiamat. Dungeons and Dragons depicts Tiamat as being a five-headed goddess of evil dragons, with each head colored one of the primary colors of chromatic dragons - blue, green, red, black, and white.
- Accordingly, "Blue-Eyes White Dragon" strongly resembles Bahamut, Tiamat's rival and god of good dragons. This is fitting, as "Blue-Eyes" is a LIGHT monster, one of two Attributes that can destroy "Five-Headed Dragon" in battle.
- Its upgrade, Dragon Master Knight was also used to combat "Five-Headed Dragon" in the anime and is one of the few cards in the real game able to destroy "Five-Headed Dragon" by battle.
- Accordingly, "Blue-Eyes White Dragon" strongly resembles Bahamut, Tiamat's rival and god of good dragons. This is fitting, as "Blue-Eyes" is a LIGHT monster, one of two Attributes that can destroy "Five-Headed Dragon" in battle.
- This monster has 5 heads: a center silver EARTH head, a mechanized WIND head, a black DARK head, a FIRE head, and a blue WATER head. There is no LIGHT based head, referencing its effect of only being able to be destroyed by LIGHT (and DIVINE) monsters.
- This monster appears in the artwork of "Paradox Fusion".
- Four of this monster's heads resemble "Serpent Night Dragon", "Darkfire Dragon", "Metal Dragon," and "Aqua Dragon".
- Coincidentally, "Serpent Night Dragon" and "Aqua Dragon" are two of the five monsters that merged to form this monster in Yu-Gi-Oh! Capsule Monsters. The other three are "Meteor Dragon", "Luster Dragon #2" and "Tyrant Dragon".
- This card has a Spellcaster-Type counterpart in "Quintet Magician", as both cards are DARK Level 12 Fusion Monsters whose Fusion Materials are 5 monsters with the same Type.
- This card has a retrained Link counterpart in Five-Headed Link Dragon.