- This monster is based off the Dungeons & Dragons representation of a Mesopotamian goddess, Tiamat. Dungeons and Dragons depicts Tiamat as being a five-headed goddess of evil dragons, with each head colored one of the primary colors of chromatic dragons - blue, green, red, black, and white.
- Accordingly, the "Blue-Eyes White Dragon" strongly resembles Bahamut, Tiamat's rival and god of good dragons.
- This is fitting, as "Blue-Eyes" is a LIGHT monster, one of two Attributes that can destroy "Five-Headed Dragon" in battle.
- Accordingly, the "Blue-Eyes White Dragon" strongly resembles Bahamut, Tiamat's rival and god of good dragons.
- The mechanized head represents the EARTH Attribute, the center yellow one represents the WIND Attribute, the black one represents the DARK Attribute, while the FIRE and WATER heads represent their own Attributes, respectively. There is no LIGHT Attribute head, referencing its effect of only being able to be destroyed by LIGHT (or DIVINE) monsters.
- This monster appears in the artwork of "Paradox Fusion".
- Four of this monster's heads resemble "Serpent Night Dragon", "Darkfire Dragon", "Metal Dragon," and "Aqua Dragon".
- Coincidentally, "Serpent Night Dragon" and "Aqua Dragon" are two of the five monsters that merged to form this monster in Yu-Gi-Oh! Capsule Monsters. The other three are "Meteor Dragon", "Luster Dragon #2" and "Tyrant Dragon".
- This card has a Spellcaster-Type counterpart in "Quintet Magician", as both cards are DARK Level 12 Fusion Monsters whose Fusion Materials are 5 monsters with the same Type.