- "Cyber-Stein" and its Japanese name, meaning "Devil Franken", are both based off Frankenstein. In the novel, Victor Frankenstein revives a dead body comprised of body parts from several different bodies, much in the same way Fusion Monsters are comprised of Fusion Material monsters, explaining why "Cyber-Stein" summons Fusion Monsters.
- This monster shares a common naming convention with another monster based off of Frankenstein's monster- Number 22: Zombiestein. In the OCG, their names contain "Franken" (Cyber-Stein's OCG name is "Devil Franken" and Number 22's is "Fran Ken") while in the TCG their names contain "Stein" instead.
- This monster appears in the artwork of "Tour Bus To Forbidden Realms".
- Before Upperdeck Day only 18 copies of the SJC-EN001 card existed in the world. $20,000 USD was bid for a "Cyber-Stein" SJC-EN001 card on eBay, but the bidder didn't pay. The card was eventually resold for approximately $7,000 USD.
- In more recent years a few copies have surfaced on card single websites for as low as $400 USD.
- "Cyber-Stein" was the first of only six cards to be banned during the middle of a banlist cycle, and not during the new banlist announcements. It was followed by "Dimension Fusion", "Temple of the Kings", "Performage Damage Juggler", "Performage Plushfire", and "Tellarknight Ptolemaeus".
- In the OCG, this card was Forbidden for sixteen formats before being Limited once more, which was the most of any card before it was surpassed by "Raigeki"'s twenty-four in the TCG.
- This card has the largest static LP cost of any card in the game.
- This is one of only two Shonen Jump Championship Prize Cards to be banned, with the other being "Crush Card Virus".
- Coincidentally, both were printed as a Rare card in Dark Beginning Volume 2 and Turbo Pack: Booster One respectively. Before "Shrink" was printed as a common, this was the lowest rarity a Shonen Jump Championship Prize Cards was printed.