- "Cyber-Stein" and its Japanese name, meaning "Devil Franken", are both based off Frankenstein. In the novel, Victor Frankenstein revives a dead body comprised of body parts from several different bodies, much in the same way Fusion Monsters are comprised of Fusion Material monsters, explaining why "Cyber-Stein" summons Fusion Monsters.
- This monster shares a common naming convention with another monster based off of Frankenstein's monster- Number 22: Zombiestein. In the OCG, their names contain "Franken" (Cyber-Stein's OCG name is "Devil Franken" and Number 22's is "Fran Ken") while in the TCG their names contain "Stein" instead.
- This monster appears in the artwork of "Tour Bus To Forbidden Realms".
- Before Upperdeck Day only 18 of the SJC-EN001 card existed in the world. $20,000 USD was bid for a "Cyber-Stein" SJC-EN001 card on eBay, but the bidder didn't pay. The card was eventually resold for approximately $7,000 USD.
- In more recent years a copy or two have surfaced on card single sites for as low as $400 USD.
- "Cyber-Stein" was the first of only three cards to be banned during the middle of a banlist cycle, and not during the new banlist announcements. It was followed by "Dimension Fusion" and "Temple of the Kings".
- This card is one of ten cards to have gone instantly from Unlimited to Forbidden. It was preceded by "Time Seal", "Victory Dragon", and "Chaos Sorcerer", and followed by "Dark Strike Fighter", "Substitoad", "Mass Driver", and "Glow-Up Bulb".
- The Dark Beginning 1 version "Flame Swordsman" has its name misprinted as "Cyber-Stein".
- This card has the largest Life Point cost to activate of any card, barring cards with variable Life Point costs such as "Solemn Judgement" and "Backs to the Wall".
- This is one of only two Shonen Jump Championship Prize Cards to be banned, with the other being "Crush Card Virus".
- Coincidentally, both were printed as a Rare card at one point. Before "Shrink" was printed as a common, this was the lowest rarity a Shonen Jump Championship Prize Cards was printed.