- Ironicly, despite being called a white dragon, Blue-Eyes is usualy depicted in the anime as a blue dragon.
- This currently has the most alternate artworks in the game with 6 (5 released in the TCG), followed by "Dark Magician" and "Red-Eyes B. Dragon", both with 5 (4 each released in the TCG.).
- With the release of Starter Deck: Kaiba Reloaded, this card is the only card that has been printed in all rarities in the TCG (except Starfoil Rare and Mosaic Rare).
- This card has several counterparts: a DARK counterpart ("Red-Eyes B. Dragon"); a Malefic counterpart ("Malefic Blue-Eyes White Dragon"); a Photon counterpart ("Galaxy-Eyes Photon Dragon"); a Tachyon counterpart ("Number 107: Galaxy-Eyes Tachyon Dragon"), a White Night counterpart ("White Night Dragon"); a Chaos counterpart ("Chaos Emperor Dragon - Envoy of the End"); a Koa'ki Meiru counterpart ("Koa'ki Meiru Maximus"); a Synchro counterpart (Azure-Eyes Silver Dragon"); and a Match winner counterpart ("Legendary Dragon of White").
- This card, along with "Dark Magician", are the only 2 cards in the game to have had an official Chinese print before the release of Starter Deck 2014 standardized Chinese as an OCG language.
- This card is the cover card for the first TCG expansion, Legend of Blue Eyes White Dragon.
- This card has the highest ATK of all Normal Monsters.
- This monster appears in the artworks of "Burst Stream of Destruction", "Dimension Explosion" and "Meteor Stream".
- In Yu-Gi-Oh! The Falsebound Kingdom, the three "Blue-Eyes White Dragons" are named Azrael, Ibris (a mistranslation of Iblis), and Djibril. These are the Islamic names for the Angel of Death, Satan ("Iblis"), and the angel Gabriel, respectively. Azrael is an informal name, only occurring in non-religious sources (including both Sikhism and some Jewish lore as well), while Iblis is the lord of the jinn, rather than the principal fallen angel.
- This card has two younger versions: a Tuner, "The White Stone of Legend", and the dragon displayed in the card "Paladin of White Dragon".
- This card is Seto's signature card. It shares its 3000 ATK power with the rivals of other series, which are Chazz's "Armed Dragon LV10", Jack's "Red Dragon Archfiend", and Kite's "Galaxy-Eyes Photon Dragon". In the Viz translation of Kaiba's duel against Ishizu, Kaiba states that the "Blue-Eyes" embodies his soul. Jack Atlas calls his "Red Dragon Archfiend" "Waga tamashi," which translates as "my very soul" in the Japanese, and Kite has called "Galaxy-Eyes Photon Dragon" "his soul" (Ore no tamashi).
- In addition, many trump cards of other archetypes also share the same ATK and DEF (such as "Horus", "Judgment Dragon", "Stardust Dragon/Assault Mode" and "Volcanic Doomfire"), and often the same Type as well.
- In some Yu-Gi-Oh! video games (Dark Duel Stories), this card has an ally, the "Mystical Elf", which can increase the ATK and DEF of this card by 500.