- This monster is the cover card for the first TCG expansion: Legend of Blue Eyes White Dragon and many other sets.
- This is the first card to be released in both the OCG and Rush Duel format.
- This monster is Seto Kaiba's signature card. It shares its 3000 ATK with the rivals of other series, which are Chazz's "Armed Dragon LV10", Jack's "Red Dragon Archfiend", Kite's "Galaxy-Eyes Photon Dragon", Declan's "D/D/D Doom King Armageddon" and Varis' "Borreload Dragon".
- "Blue-Eyes White Dragon" began the tradition of the main protagonists of each Yu-Gi-Oh! series facing against a monster of 3000 ATK in their very first duel of the series and winning the duel by defeating said monsters.
- After "Token", this card has the most alternate artworks in the OCG/TCG with eight in total, beating out the next contender, "Dark Magician", by one. This excludes "Dark Magician Girl", who has multiple different Japanese and international artworks.
- In Yu-Gi-Oh! (1999 film), it is said that this card is a symbol of power, and "Red-Eyes" is a symbol of potential. Also, "Blue-Eyes White Dragon" symbolizes pride and destruction, while "Red-Eyes" symbolizes violence and anger.
- With the release of Starter Deck Kaiba Reloaded, this card is the only card that has been printed in all rarities in the TCG (except Starfoil Rare, Shatterfoil Rare and Mosaic Rare).
- This card has several counterparts.
- A retrained counterpart: "Blue-Eyes Alternative White Dragon"
- An advanced counterpart: "Blue-Eyes Shining Dragon"
- Two Synchro counterparts: "Azure-Eyes Silver Dragon" and "Blue-Eyes Spirit Dragon"
- Two Ritual/"Chaos" counterparts: "Blue-Eyes Chaos Dragon" and "Blue-Eyes Chaos MAX Dragon"
- A DARK counterpart: "Red-Eyes Black Dragon"
- A "Malefic" counterpart: "Malefic Blue-Eyes White Dragon"
- A "Toon" counterpart: "Blue-Eyes Toon Dragon"
- A Match winner/Xyz counterpart: "Legendary Dragon of White"
- This monster appears in the artworks of "Burst Stream of Destruction", "Dimension Explosion", "Dragon's Fighting Spirit", "Majesty with Eyes of Blue", "Meteor Stream", "Rage with Eyes of Blue", "Successor Soul", "Destined Rivals", and "Mystical Elf - White Lightning".
- This card's original OCG artwork is taken directly from the manga card artwork, which made its first appearance in Yu-Gi-Oh! Duel 9: "The Cards with Teeth (Part 1)"
- This card's third and fourth OCG/TCG artworks are taken from this monster's depiction on the title page of Yu-Gi-Oh! Duelist Duel 41: "Duel Disk Battle!".
- In Yu-Gi-Oh! The Falsebound Kingdom, the three "Blue-Eyes White Dragons" are named Azrael, Ibris (a mistranslation of Iblis), and Djibril.
- In the Yu-Gi-Oh! manga and anime series, there's a mysterious woman named Kisara that carries the spirit of the Blue-Eyes White Dragon. "Maiden with Eyes of Blue" is based on her.
- The Weekly Shonen Jump March 2014 membership promotional version of "Blue-Eyes White Dragon" is the first card to be printed with an italicized Matrix typeface used for its card text. On every card before it, the Matrix font is only used in regular type (not bold, not italic).
- Ironically, while this card has been printed in several sets in the TCG/OCG, making it one of the most common cards of all time, this card is one of the rarest officially-printed cards of all time in the anime/manga with only 4 copies having been printed ever.
- The Jump Ryū Vol.08 promotional card print of this card features Seto Kaiba in its artwork.
- In the video game Yu-Gi-Oh! Duel Links, when this card is summoned by Kaiba the summon animation is altered during April Fools' Day 2017. In this animation "Blue-Eyes" wears a KaibaConstruction construction helmet - similar to the sketch shown during game maintenance periods when attempting to log in, and a sign in Yu-Gi-Oh! The Dark Side of Dimensions.