- This card can be searched by "Dogu", "Single Purchase", "Painful Escape", "Mound of the Bound Creator" and "The True Name".
- "The First Monarch" can help Tribute Summon this card. Using its effect, discard a monster that can be Special Summoned from the Graveyard immediately after discard and declare the DIVINE Attribute to change the Attribute of "The First Monarch". Then simply Tribute both monsters.
- "Twin-Headed Behemoth", "Soul Exchange", "Double Summon", "D-Boyz" and "Gilasaurus" are recommended cards to Summon "Slifer" faster.
- A great engine for Summoning "Slifer" are "Frogs". Any combined effects of "Treeborn Frog", "Swap Frog" or "Ronintoadin" could be used to bring "Slifer" to the field.
- "Tethys, Goddess of Light" is very easy to use in a high "Fairy-Type count" Deck that can be Summoned with "Valhalla, Hall of the Fallen", with a very easy to use effect with cards like "Magical Mallet" and "Reload".
- Use "Reckless Greed" to get more ATK immediately. Since it is a Trap Card, it can be useful if your opponent attacks "Slifer".
- Combo this card with "Burden of the Mighty" to destroy more powerful monsters that the opponent Summons.
- This card can be useful against most modern combo Decks if you manage to field it. Generally, many combo starters and low Link Rating monsters have low ATK, so this card will destroy almost any monster that is Summoned to start a combo on the opponent's field.
- The effect of "Morphing Jar" can help keep this card's ATK high.
- Using "Card of Safe Return" along with "Manticore of Darkness" can allow yourself to draw without limit. This potentially can increase this card's ATK to become close to the Deck capacity x1000, or ~40,000 ATK.
- "Maxx "C"" can easily allow "Slifer" to gain at least 1000 ATK during the turn that it is played, although if it is already on the field, it is unlikely that the opponent will swarm with anything due to its destructive effect, so it might be a great idea to play "Maxx "C"" a turn in advance to Summoning "Slifer".
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