- This card can be searched by "Dark Sage", "Ancient Gear Drill", "Alchemic Magician", "Angmarl the Fiendish Monarch", "Magical Burst", and "Left Arm Offering".
- "Fusion Substitute" can be discarded as cost, since it is always treated as "Polymerization". Afterwards, it can be banished in order to return the sent Fusion Monster to the Extra Deck and provide a draw.
- This card can be used to send Fusion Monsters that in turn are Fusion Materials themselves along with a monster in your hand from the Extra Deck to the GY. Then you can use those materials with cards like "Invocation", "Miracle Fusion", "Dragon's Mirror", and "Magicalized Fusion".