- This card can be searched by "Dark Sage", "Ancient Gear Drill", "Alchemic Magician", "Angmarl the Fiendish Monarch", "Mythical Bestiamorph", "Cyberse Clock Dragon", and "Left Arm Offering".
- This card is especially useful in certain Decks:
- In "Cyber Dragon" Decks, this card can be used to target "Cyber Dragon Core"/"Herz" to Special Summon 2 "Cyber Dragons". "Cyber Dragon Nova" can then be Xyz Summoned, followed by "Cyber Dragon Infinity" or they can be used to Fusion Summon any Cyber Dragon related Fusion Monster such as "Chimeratech Rampage Dragon", etc.
- Also in a Cyber Dragon Deck: Normal Summon 1 "Cyber Dragon Core" and use its effect to search either "Cyber Emergency" or "Cyber Repair Plant". Activate the Spell to add a "Cyber Dragon Vier" to the hand, then use this card on "Cyber Dragon Core" to bring out two copies of "Cyber Dragon", triggering the effect of "Cyber Dragon Vier" in your hand, which Special Summons itself leaving four Effect Monsters on field granting a Link-3 or Link-4 Summon.
- This card is very effective in "Deskbot" Decks, since all of their Main Deck monsters are potential targets. It also can trigger the effect of "Deskbot 001", "Deskbot 002" and/or "Qliphort Genius".
- It can be used to Special Summon 2 "Ancient Gear Box" and enable the Fusion Summon of an "Ancient Gear" monster or an Xyz/Link Summon.
- In a "Morphtronic" Deck, this card can be used to to get 3 copies of "Morphtronic Celfon" in Attack Position, whose effects can then be used to swarm the field.
- The Special Summoned monsters can be used as Tributes for monsters like "Destiny HERO - Plasma", "Beast King Barbaros", etc.
- "DNA Surgery" can be used to turn all monsters on the field into Machines, so that almost any Main Deck monster with up to 500 ATK can be targeted by this card.
- Machine monsters with 500 or less ATK that can be Special Summoned from the Deck:
|Japanese name||Primary type||Secondary type||Attribute||Level||PS||ATK||DEF|
|Ancient Gear (card)||古代の歯車||Effect Monster||EARTH||2||100||800|
|Ancient Gear Cannon||古代の機械砲台||Effect Monster||EARTH||2||500||500|
|Boot-Up Soldier - Dread Dynamo||起動兵士デッドリボルバー||Effect Monster||EARTH||4||0||2000|
|Cyber Dragon Herz||サイバー・ドラゴン・ヘルツ||Effect Monster||LIGHT||1||100||100|
|Cyber Dragon Nachster||サイバー・ドラゴン・ネクステア||Effect Monster||LIGHT||1||200||200|
|Cyber Ouroboros||サイバー・ウロボロス||Effect Monster||DARK||2||100||600|
|Cyber Pharos||サイバー・ファロス||Effect Monster||LIGHT||1||0||2100|
|Darksea Float||ダークシー・フロート||Effect Monster||DARK||1||0||300|
|Darksea Rescue||ダークシー・レスキュー||Effect Monster||DARK||1||0||0|
|... further results|
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