• Play this card, then Tribute your "Red-Eyes B. Dragon" to Special Summon "Red-Eyes Darkness Dragon", so a 2700+ powerhouse can attacked after inflicting the damage.
  • Even if there are hardly any cards in your hand after getting out "Red-Eyes B. Dragon", "Serial Spell" can be Chained and send the 1 or 2 remaining cards in your hand to deal out 4800 in one turn.
  • If your opponent has 1700 LP or less, use "Elemental HERO Prisma" to reveal "B. Skull Dragon", sending "Red-Eyes" to copy its name. Then "Inferno Fire Blast" can be used for 1700 direct damage, thus winning the duel.
  • This card can be used to get around an effect that would make your "Red-Eyes B. Dragon" unable to attack (i.e. "Gravity Bind", "Tribute Doll", "Spirit Reaper", etc.).
    • Or a card that lowers your monster's ATK.
  • Use this card with a monster that was Summoned with "Red-Eyes Fusion", as that card will treat that monster as the original "Red-Eyes B. Dragon". Any of the applicable targets, "B. Skull Dragon", "Meteor B. Dragon", "Archfiend Black Skull Dragon" and "Meteor Black Comet Dragon", have more ATK than the original "Red-Eyes", allowing yourself to inflict more damage.
    • If there are three copies of this card in your hand after Fusion Summoning with "Red-Eyes Fusion", use them to deal effect damage, that can range from 9600 (if "B. Skull Dragon" or "Archfiend Black Skull Dragon" is Summoned) to 10500 (if "Meteor B. Dragon" is Summoned). This leads to an OTK most of the time.
    • If "Meteor Black Comet Dragon" is Summoned, an OTK (or even an FTK) can be achieved after using its effect and sending any Level 7 or higher "Red-Eyes" monster (since the ones with lower Level don't have enough ATK for the OTK), and then using two copies of this card.
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