- Before "Gandora the Dragon of Destruction" is destroyed by its effect, use "Metamorphosis" to summon "Cyber Twin Dragon".
- You can use "Ceasefire" or "Book of Taiyou" to get this card on the field without summoning it so it won't be Destroyed by its own effect.
- You can easily Tribute Summon this card with "Fires of Doomsday" or "Stray Lambs" and Tribute Set it.
- This card can be used with "Crush Card Virus", "Deck Devastation Virus" and "Eradicator Epidemic Virus" depending on how many cards it removes.
- Mausoleum of the Emperor is great with this card as it allows you to keep monsters you have as food for this beastly card.
- This card works fairly well with a Deck relyingon removing things from play, also know as a Macro Deck. This is because you can use Macro's "D.D. Survivor" and "D.D. Scout Plane as Tribute fodder, and because this card's field nuke attack removes cards from play when it destroys them.