- Set this card on the field, then use "Book of Moon" to keep the card on the field, then each turn you can pay half of your life points to "nuke" the field and have this card increase its ATK.
- You can use "Burial from a Different Dimension" to bring back 3 monsters banished to your graveyard, and use "Monster Reincarnation" to bring one of them to your hand.
- This card can be searched via "Sangan".
- This card can be Tribute Summoned with one tribute using "Double Coston" or "Totem Dragon", which will allow you to keep one extra monster on the field.
- Use "DNA Surgery" and "Telekinetic Charging Cell", and the cost for Gandora's effect can be nullified, albeit for only one turn due to the nature of his effect.
- You can easily Tribute Summon this card with "Fires of Doomsday" or "Stray Lambs" and Tribute Set it.
- "Mausoleum of the Emperor" is great with this card as it allows you to keep two extra monsters you have as fodder.
- You can also use "Star Blast" since it costs the same amount of Life Points to make this card summonable.
- Using "Gilasaurus" as tribute fodder is also a good idea; your opponent will summon an additional card to be removed from play, which would otherwise be disadvantegous.
- This card works fairly well in a Macro Deck. You can use it's effect while you control "D.D. Survivor" and/or "D.D. Scout Plane". This cards effect will Banish then, which means they will return to the field during the End Phase.
- You can use "Dimensionhole" to Banish this card then have it come back later on to use its effect again, or even as Tribute fodder.
- Use "Herald of Creation" to return this card to your hand.
- This card can be used to destroy "Sphinx Teleia" and "Andro Sphinx" at the same time, letting you summon "Theinen the Great Sphinx"
- You can recycle this card with "Dark Eruption" and "Recurring Nightmare".
- In a Dinosaur deck, this card can be used to power up "Tyranno Infinity".
- Summon "Phantom of Chaos" and Banish this card from your Graveyard then clear the field.
- Before it gets destroyed by its effect, you can Tribute this card for "Advance Draw", "Mystik Wok" or other cards like them.
- This cards effect can trigger your own "Starlight Road", albeit at a hefty cost.
- Use this card with "Future Visions" to dodge the self-destruct effect.
- In a Dragon Deck, you can tribute summon this card to remove from play all monsters on your opponent's field, then remove it from play for "Red-Eyes Darkness Metal Dragon". Then you can use the effect of "Red-Eyes Darkness Metal Dragon" to special summon another Dragon for two direct hits.
- Equip this card with Equip Spell Cards that boost ATK after using its effect to increase the direct damage your opponent takes.
- Use this card effect while you're controlling "Gaia Drake, the Universal Force". Gaia will not be destroyed by Gandora effect.
- Set "Xyz Dimension Splash" before you summon this card. Upon summoning it, Gandora will Banish it, activating its effect and summoning 2 Level 8 WATER-type monsters to the field, and then Xyz summon for a Rank 8 monster that requires 2 or 3 Xyz monsters for an easy OTK. (most easily achievable with "Megamorph" and "Neo Galaxy-Eyes Photon Dragon")
- You can use "Megamorph" after activating Gandora's effect, since you will very likely have fewer Life Points than your opponent. This can easily result in an OTK.
Traditional Format
- This card can be searched via "Witch of the Black Forest".
- Before this card is destroyed by its effect, use "Metamorphosis" to summon "Cyber Twin Dragon".