- This card can be searched by "Dark Sage", "Ancient Gear Drill", "Alchemic Magician", "Angmarl the Fiendish Monarch", "Left Arm Offering", "Spell Calling", "Quick Booster", "Mecha Phantom Beast Jaculuslan", "Synchro Fusionist", "Sabatiel - The Philosopher's Stone", "Predaplant Chimerafflesia", "Predaplant Darlingtonia Cobra", "Supreme King Gate Zero", and "Cyberdark Inferno".
- This card can be used during the Battle Phase, after attacking with all Fusion Materials, in order to attack with the newly Fusion Summoned monster.
- You can then later use "De-Fusion" after attacking to get back the fusion materials for even more attacks while maintaining field presence.
- With "Mound of the Bound Creator" on the field, this card can be used to Fusion Summon a Level 10 or higher monster, so that it won't be destroyed during the End Phase.
- This card works extremely well with "Chain Material" since "Chain Material" overcomes this card's weakness of being only able to use monsters you control for a fusion and this card overcomes Chain Material's weakness of needing to survive an entire turn on the field.
- Use this card to Fusion Summon "Elemental HERO Absolute Zero", "Panzer Dragon" or "Starving Venom Fusion Dragon" to trigger their destruction effects when they are destroyed by this card's effect.
- In a Machine Deck, this card and "Cybernetic Fusion Support" can be used to summon a boss monster like "Chimeratech Overdragon" or "Chaos Ancient Gear Giant" and OTK the opponent.
- After equipping at least one of two Gemini monsters on your field with "Supervise" and attacking with both, Fusion Summon "Superalloy Beast Raptinus" using the equipped monster as material. "Supervise" will then revive a Normal Monster or Gemini monster from your Graveyard to bring even more damage potential.
- Since the Summoned Gemini will have its effect thanks to "Raptinus", "Chthonian Emperor Dragon" is a good option, bringing two attacks for a combined 4800 extra damage on top of 2200 from "Raptinus". If the material of "Supervise" was "Chthonian Emperor Dragon", the damage potential for the combo exceeds 11,800.
- Other Fusion Monsters that can be Fusion Summoned by this card without being destroyed by it include "Bloom Diva the Melodious Choir", "Eldlich the Mad Golden Lord", "Frightfur Sabre-Tooth" (with 3 or more materials), "Gravekeeper's Supernaturalist" (if you control "Necrovalley"), "Red-Eyes Dark Dragoon" and "Ultimate Axon Kicker".