This is a list of Monster Cards with 250 DEF.
- For a list of monsters with 250 ATK, see 250 ATK Monster Cards.
OCG/TCG Monster Cards with 250 DEF
| Japanese name | Primary type | Secondary type | Attribute | Type | Level/ Rank | ATK | |
|---|---|---|---|---|---|---|---|
| Galaxy-Eyes Cloudragon | 銀河眼の雲篭 | Effect Monster | LIGHT | Dragon | 1 | 300 | |
| Gunkan Suship Shirauo | しらうおの軍貫 | Effect Monster | FIRE | Aqua | 4 | 200 | |
| Gunkan Suship Shirauo-class Carrier | 空母軍貫－しらうお型特務艦 | Effect Monster Xyz Monster | FIRE | Aqua | 4 | 2200 | |
| Milus Radiant | ミリス・レディエント | Effect Monster | EARTH | Beast | 1 | 300 | |
| Ooguchi | ラージマウス | Effect Monster | WATER | Aqua | 1 | 300 | |
| Sinister Serpent | キラー・スネーク | Effect Monster | WATER | Reptile | 1 | 300 | |
| Swordsman from a Distant Land | 異国の剣士 | Effect Monster | EARTH | Warrior | 1 | 250 | |
| Tachyon Cloudragon | 時空の雲篭 | Effect Monster | LIGHT | Dragon | 4 | 300 | |
| The White Stone of Legend | 伝説の白石 | Effect Monster | Tuner monster | LIGHT | Dragon | 1 | 300 |